Single Live Cell Imaging and Scanning Ion Conductance Microscopy

XE-Bio is a powerful 3-in-1 nanoscience research tool that uniquely combines Scanning Ion Conductance Microscopy (SICM) with True Non-Contact mode AFM and inverted optical microscope on the same platform. The modular design of  XE-Bio allows easy exchange between SICM and non-contact AFM. Designed for single live cell imaging, the combined imaging capability of SICM, AFM, and inverted optical microscope makes XE-Bio ideal for imaging biological samples, such as single living cells, in dynamic conditions. Moreover, SICM can be adapted to enable a host of powerful applications in nanoscale electrophysiology.

Powerful 3-in-1 Nanoscale Research Tool with Modular Platform
  • Scanning Ion Conductance Microscopy (SICM)
  • True Non-Contact mode Atomic Force Microscope (AFM)
  • Inverted Optical Microscope

Non-invasive In-liquid Imaging by SICM
  • Monitoring ion channels of single living cells
  • Unique functional capability of targeted localized stimulation
  • Enable nanoscale patch-clamping for electrophysiology
  • Environmental chamber for temperature, pH, and humidity control

Ultimate AFM Resolution by True Non-Contact Mode^TM
  • 10 times larger Z-scan bandwidth than a piezotube
  • Less tip wear for prolonged high-quality and high-resolution imaging
  • Minimized sample damage or modification
  • Immunity from parameter-dependent results observed in tapping imaging
  • Single molecule Force-Distance spectroscopy with automated data analysis

Fully Integrated Inverted Optical Microscope
  • Compatible with phase contrast and DIC imaging
  • Also compatible with fluorescence microscopy
  • Advanced image overlay functions