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Analyze Cells with Park Scanning Probe Microscopy

Brian Choi, (This email address is being protected from spambots. You need JavaScript enabled to view it.) Bio-application scientist
Sample courtesy : Prof. Ushiki, Niigata Univ.

Scanning ion conductance microscopy (SICM) is a new nanoscalemicroscopy specially developed for biological object observation in liquid environments. The nanoscale high-resolution of SICM enables visualizing the details of biologically   important features of a size not observable with conventional    optical microscopy. SICM’s in-liquid imaging capability allows     biologists to observe morphology of biological features as never before possible with scanning electron microscopy (SEM). SICM opens up a new era of microscopic research for biology and life  science.  

• SICM overcomes the resolution limit of optical microscope (Imaging resolution of SICM ≒ 50 nm)
• SICM does not cause morphological deformation (non-destructive, non-physical contact)
  • Discover the physiological phenomena of cells at nanoscale
  • Directly acquire a cell’s morphology in-buffer without sample preparation
  • Image delicate cell morphology from sub-cellular to tissue level

Scanning Ion Conductance Microscope
Neuronal Netwrok, measured in fluid


Configuration of SICM Nano-pipette End Opening (SEM image)

SICM is a type of scanning probe microscopy and was invented in 1989 in Prof. Hansma’s group. Unlike optical microscopes, SICM uses a glass nanopipette as a sensitive probe with an electrode inside of it. The glass pipette detects nearby surfaces via a decrease in the ion current flow through the pipette.


Park Cell Analysis Systems

  park-analyze-cell-nx-bio park-analyze-cell-nx10 park-analyze-cell-xe7
  Park NX-Bio Park NX10 Park XE7
Scanning Ion Conductance Microscopy (SICM)  
Atomic Force Microscopy (AFM) with liquid probe hand
Inverted Optical Microscopy (IOM)    
Live Cell Chamber    

Analyze Cells - SICM | Atomic Force Microscopy |Park Systems