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Cell Discovery Like Never Before
Nano-bioscience holds the promise of solving medical problems of great importance. Over the years, various technologies have been developed to unlock the mysteries of many different subjects in this field. One of the keys to understanding life is to discover how individual cells work. This requires experimentation on live, single cells that can’t be seen by the human eye with ordinary microscopes. Park Systems is the pioneer and leader in non-invasive in-liquid imaging of single live cells and innovative functional studies on the localized ion channel activities.
Discovering a New Realm in Live Cell Imaging
Cellular membrane surfaces are transparent to optical microscopy methods, and too soft to produce any contrast or even endure probing by conventional AFM method. Scientists need a non-invasive nanoscale tool that enables the local probing of live cellular membranes to achieve their research goals. Scanning Ion Conductance Microscopy (SICM) is the non-invasive in-liquid scanning probe technique that does not apply any force over its sample surface, making it ideal for nanoscale imaging of soft cellular membranes.
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>>See more live cell
images by Scanning Ion Conductance Microscope (SICM)
Enabling Innovation in Single Cell Research
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Non-invasive in-liquid scanning probe technique like SICM enables the imaging of live cellular membrane, and helps researchers to understand cell morphology and functional development of the cell surface heretofore hidden beneath the cytoskeleton. Since live cells can be imaged with SICM over long period of time with no sign of deterioration, after obtaining a large-size image, it is easy to zoom in and monitor local dynamic change of various regions of cell surface. This allows various researches on single living cells by connecting detailed structural features to cellular functions, including functional mapping on membrane features.
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Live COS-1 Monkey Kidney Cell Imaged by SICM (10 μm x 10 μm)
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Unique Functional Capabilities on the Ion Channel of Live Cells
SICM provides the integrated information on nanoscale biological surfaces, enabled by superior non-invasive in-liquid imaging on soft cellular membranes and unique functional capability to monitor the ion channels of single living cells, the key quantifier of various cellular activities. Hence, dynamic information about the biological functioning of a single, living cell can be obtained by performing targeted localized stimulation and SICM-based nanoscale patch-clamping.
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Product Solutions for Biological Science
True Non-Contact ModeTM is ideal for imaging soft biological samples because it provides a method for measuring sample topography with minimal or no contact between the tip and the sample surface. Scanning Ion Conductance Microscopy does not apply any force over its sample surface, making it ideal for nanoscale imaging of soft cellular membranes in liquid. Combining these two unique capabilities in its product offering, Park Systems provides the following non-invasive, in-liquid imaging solutions that enable the localized imaging and functional studies on single living cells.
XE-Bio
A powerful 3-in-1 nanobio research tool that uniquely combines industry’s only True Non-Contact AFM with
Scanning Ion Conductance Microscopy (SICM) and inverted optical microscope on the same platform
XE-120
Versatile AFM place on top of the many popular inverted optical microscopes with flexible integration for other
advanced optical measurement techniques such as Raman spectroscopy
Live Cell Chamber Option
Industry’s only live cell chamber keeps live cells alive during long hours of sample
measurement in a controlled environment of temperature, pH (CO2), and humidity.
Target Applications for Biological Science
Scanning Ion
Conductance Microscopy (SICM)
DNA
Oligonucleotides
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AFM
Solutions
Biological Science
