Scanning Ion Conductance Microscopy (SICM)
Similar to Scanning Tunneling Microscopy in ambient air, SICM operates in liquid without any physical contact with or force applied to sample surface. A glass nanopipette probe filled with an electrolyte senses ion current to feedback its position relative to a sample completely immersed in a liquid buffer. Since the probe-sample distance is maintained by keeping the ionic current constant instead of applying a physical force to the sample, it is an ideal tool to obtain stable images of soft and sticky biological samples in liquid.
For the product information of this advanced SPM mode offered by Park Systems, please click here.