Advanced SPM Modes

Chemical Force Microscopy (CFM) with Functionalized Tip

         (a) Glucose Bimolecular Force Measurement Between Mica                (b) Glucose Bimolecular Force Measurement Between Glucose           surface and Gox-Casein Tip                                                                    and Gox-Casein Tip         

CFM measures the chemical interactions between functionalized tips and sample to determine the chemical nature of surfaces and facilitate studies of chemical bonding enthalpy and surface energy. Tips are typically gold-coated and functionalized with R-SH thiols, R being the functional groups of interest such as -CH, -COOH, -NH, and -OH.